The coronavirus vaccine is one of its kind: welcome to the new age of mRNA vaccines

Up until now, vaccines have either been live attenuated or dead (inactivated) vaccines.

Here’s what that means:
A live attenuated vaccine is derived from a live virus or bacteria that is weakened and injected into the body to trigger an immune response. Currently, live-attenuated vaccines include the measles, mumps, polio, varicella, influenza, yellow fever vaccines. A live, attenuated vaccine can theoretically revert to its original disease-causing form.

Inactivated vaccines are produced by growing the virus or bacteria in culture media, then inactivating it with heat or chemicals. Inactivated vaccines are dead and cannot multiply. They always require multiple doses in order to be effective. Examples of inactivated vaccines include those that prevent against meningococcus, pneumococcus, Haemophilus influenzae and Salmonella typhi.

mRNA vaccines are different because they don’t train the immune system to recognize the virus or bacteria, by injecting elements of the organism, rather the genetic sequence that codes for it.

“mRNA vaccines, in contrast, trick the body into producing some of the viral proteins itself. They work by using mRNA, or messenger RNA, which is the molecule that essentially puts DNA instructions into action. Inside a cell, mRNA is used as a template to build a protein. ‘An mRNA is basically like a pre-form of a protein and its (sequence encodes) what the protein is basically made of later on.’

To produce an mRNA vaccine, scientists produce a synthetic version of the mRNA that a virus uses to build its infectious proteins. This mRNA is delivered into the human body, whose cells read it as instructions to build that viral protein, and therefore create some of the virus’s molecules themselves. These proteins are solitary, so they do not assemble to form a virus. The immune system then detects these viral proteins and starts to produce a defensive response to them.”

What are the pros for this new type of vaccine?
While there are concerns that this is the first time an mRNA vaccine has ever been licensed for human use, mRNA vaccines are potentially more potent and straightforward to produce than traditional vaccines. As a result, it will be easier to ramp up its production, which is important for the large-scale vaccination that will take place to ensure the safe re-opening up of essential economic and life activities.

Read more here
https://horizon-magazine.eu/article/five-things-you-need-know-about-mrna-vaccines.html
https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/prinvac.pdf

What you have never told me is this: is this coronavirus disease unique in its manifestation. Are its symptoms so clear that it can’t be possibly mistaken for something else (the way Ebola or Cholera symptoms are always very clear)? Or are we at risk of attributing all respiratory deaths to ‘corona’ [knowing that all along, respiratory diseases have been the leading causes of death]? I read the procedure here in Kenya is to treat all cases of pneumonia and asthma-like symptoms as suspected coronavirus. So if a person has pneumonia, and he happens to be coronavirus positive, it is treated as coronavirus. If a person dies from asthma as a certain DJ from kiambu died, he is treated as a coronavirus death, even when the results come negative. Yet we hadn’t done serologic surveys beforehand, to understand how prevalent this coronavirus is in the first place.
So my question is that one – on whether coronavirus disease is so unique in its manifestation that it can’t possibly be mistaken for anything else, or if our mind are being played with. I am asking this because you once posted photos of the coronavirus situation from the hospital you work in, meaning that you had encountered real life coronavirus.

I found this very fascinating. I heard Gates describe it sometime back and I was impressed. I can imagine it being used to treat HIV in time. Imagine if the mRNA advances enough to code for the production of entire antibodies. You could get mRNAs to instruct the formation of white blood cells with CCR5-delta 32 mutations. The first medical recovery from HIV was recorded in someone who got bone marrow transplants from a ccr5-delta 32 donor. I imagine with time mRNAs may be used to code for equivalent white blood cells without transplants… That’s my prediction

But this also means all this time, there would have been a vaccine for HIV & Ebola? Perhaps not enough stimulus to save African lives?

Yep, even cancer will one day be treated/prevented by use of mRNA vaccines.

Madagascar all the way.

There’s overlap between Sars-CoV-2 and influenza. The latter tends to present very abruptly though less severe and deadly than the former. With covid, the loss of sense of smell & taste, shortness of breath, fatigue is more pronounced, the fevers are higher…In the setting of these symptoms and a positive test, the obvious conclusion is to treat it as much.
Viruses, including influenza, can set up a conducive environment for superimposed bacterial pneumonia. That’s why everyone with covid-19 gets antibiotics as part of their treatment regimen.

Regular old bacterial pneumonia caused by Streptococcus pneumoniae tends to be lobar pneumonia, which means it’s sort of confined to one area of the lung. Within a few days of rapid detection and treatment, majority of patients will recover from bacterial pneumonia. In general, their chest x-rays look like this…
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With covid-19 pneumonia, the lung manifestations tend to be more diffuse and involve both regions of the lung. Unfortunately, most patients at this juncture will deteriorate and enter into a state called ARDS (acute respiratory distress syndrome) characterized by severe hypoxia (lack of oxygen) despite administering high concentrations of oxygen through the ventilator.
Also with covid-19, we’re seeing cases of thromboembolic manifestations which are less common in other forms of pneumonia.

A chest x-ray in someone with covid-19 pneumonia will look like this.
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In the beginning of every zombie movie…

The apocalypse is always triggered by a cancer cure that acts by tweaking DNA

Stock up on guns :slight_smile:

kwani iko na tupins uko ndani?

Haha!:smiley:

Thankfully this won’t be a DNA vaccine which must integrate with the host genome and can result in insertional mutagenesis…and human zombies. :smiley:
An mRNA vaccine only has to get the cell cytoplasm to start producing the viral proteins. Moreover it has a short half life before it degrades.

Thank you, though I fear that we may have taken old conditions that there were always there and baptized them /attributed them to ‘covid-19’. Initially, I thought that coronavirus was truly a new disease with new/unique symptoms that were never seen in anything before to justify the measures we are having to put in place on its account. But now I don’t know.

Why has the mrna vaccine not been used before yet from your explaination it sounds the best

The science was first conceptualized in the 1990s but these things take time to get going.

It can’t be understated that Bill and Melinda Gates have invested billions and billions of dollars which has resulted in explosive discoveries in the field of immunotherapy. What we know of mRNA vaccines actually comes from cancer research.
When the SARS pandemic came out in 2002-2003, they developed an mRNA vaccine against it but the virus sort of fizzled out so it wasn’t mass produced. Ebola, Zika virus and rabies virus all have mRNA vaccines in various stages of clinical trials. m-RNA vaccines against prostate cancer, non-small cell cancer and melanoma are also in clinical trials. Slowly but surely, biologics (cancer proteins that are injected into the body to act as antigens and stimulate an immune response) are replacing regular chemo because they are targeted to the cancer cell so even the side effect profile is better. One reason why cancer cells proliferate, is because they start out as normal cells so the immune system doesn’t recognize them as foreign. Sometimes the immune system can recognize cancer cells as foreign but the attack is not strong enough to destroy it. Now imagine if the immune system had been primed for attack much earlier by teaching it how to respond before a cancer cell ever started growing? It’s a really good idea and super effective because cancer cells produce unique proteins whose genetic sequence can also be reverse engineered to mRNA. The cure for cancer will most likely come in the form of a mRNA vaccine.

https://www.yahoo.com/news/scientists-china-believe-drug-stop-pandemic-without-vaccine-042422069.html

Is this a viable path?

This vaccine thing is very problematic imo
So many questions
Eg why is it so necessary if the fatality rate is below 1%? Does recovering from covid confer immunity? Will this vaccine have undergone sufficient trials? Is it a vaccine against all strains of covid? What if it mutates? Flu vaccine exists yet it still kills tens of thousands annually in the US alone… Sembuse covid?

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Most young healthy people do not need this COVID vaccine as they can simply develop immunity naturally. What tgey need is HIV and cancer vaccine. But since the old dogs are the ones with money they priotise on covid which more deadly to that age bracket.